A non-canonical SWI/SNF complex is a synthetic lethal target in cancers driven by BAF complex perturbation

Brittany C. Michel, Seth H. Cassel, Nazar Mashtalir, +15

Nature Cell Biology

Non-canonical Swi/snf ComplexOncogenic AgentMedicineSynthetic Lethal TargetCancer Genomics +7

An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells

Ekaterina V. Vinogradova, Xiaoyu Zhang, David Remillard, +25

Cell

Electrophile-cysteine InteractionsSignal TransductionBiochemistryCell InteractionCell Trafficking +8

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

David Remillard, Dennis L. Buckley, Joshiawa Paulk, +8

Angewandte Chemie International Edition

Chemical BiologyInorganic ChemistryHeterobifunctional LigandsChemical ProbesBiochemistry +13

Targeted degradation of BRD9 reverses oncogenic gene expression in synovial sarcoma

Gerard L. Brien, David Remillard, Junwei Shi, +14

eLife

Synovial SarcomaOncogenic AgentMedicineImmunologyCharacteristic Fusion Protein +13

Targeted Protein Degradation by Electrophilic PROTACs that Stereoselectively and Site-Specifically Engage DCAF1

Yongfeng Tao, David Remillard, Ekaterina V. Vinogradova, +7

Journal of the American Chemical Society

Engage Dcaf1Protein FunctionSignal TransductionBiochemistryProtein Assembly +13

Chemical Proteomic Discovery of Isotype‐Selective Covalent Inhibitors of the RNA Methyltransferase NSUN2

Yongfeng Tao, Jan G. Felber, Zhongyu Zou, +9

Angewandte Chemie International Edition

Collateral lethality between HDAC1 and HDAC2 exploits cancer-specific NuRD complex vulnerabilities

Yuxiang Zhang, David Remillard, Ugoma Onubogu, +12

Nature Structural & Molecular Biology

Tumor BiologyGenome InstabilityMedicineMolecular BiologyCollateral Lethality +5

A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer

Helen Tanton, Tomasz Sewastianik, Hyuk‐Soo Seo, +15

Science Advances

Cancer ResearchOncologyOncogenic AgentMedicinePharmacology +12

Degradation of the BAF Complex Factor BRD9 by Heterobifunctional Ligands

David Remillard, Dennis L. Buckley, Joshiawa Paulk, +8

Angewandte Chemie

Assessment of Bromodomain Target Engagement by a Series of BI2536 Analogues with Miniaturized BET‐BRET

Luke W. Koblan, Dennis L. Buckley, Christopher J. Ott, +10

ChemMedChem