Rapid assessment of a novel series of selective CB2 agonists using parallel synthesis protocols: A Lipophilic Efficiency (LipE) analysis

Thomas Ryckmans, Martin P. Edwards, Val A. Horne, +6

Bioorganic & Medicinal Chemistry Letters

Parallel Synthesis ProtocolsBiochemistryFunctional SelectivityMedicineLipophilic Efficiency +6

Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of <i>Pseudomonas aeruginosa</i>

Roman Sommer, Stefanie Wagner, Katharina Rox, +11

Journal of the American Chemical Society

GlycobiologyDrug ResistanceMedicinal ChemistryBiofilm FormationAntimicrobial Therapy +15

The Discovery of a Potent, Selective, and Peripherally Restricted Pan-Trk Inhibitor (PF-06273340) for the Treatment of Pain

S. Skerratt, Mark D. Andrews, Sharan K. Bagal, +14

Journal of Medicinal Chemistry

Pain TherapyDrug TargetPan-trk InhibitorPain MedicineImmunology +19

Anti-biofilm Agents against <i>Pseudomonas aeruginosa</i>: A Structure–Activity Relationship Study of <i>C</i>-Glycosidic LecB Inhibitors

Roman Sommer, Katharina Rox, Stefanie Wagner, +10

Journal of Medicinal Chemistry

First dual NK1 antagonists–serotonin reuptake inhibitors: synthesis and SAR of a new class of potential antidepressants

Thomas Ryckmans, Laurent Balançon, Olivier Berton, +7

Bioorganic & Medicinal Chemistry Letters

Functional SelectivityMedicinePsychotropic MedicationNeuropharmacologyNew Class +4

Design and pharmacological evaluation of PF-4840154, a non-electrophilic reference agonist of the TrpA1 channel

Thomas Ryckmans, Aisah A. Aubdool, Jennifer V. Bodkin, +12

Bioorganic & Medicinal Chemistry Letters

Trpa1 ChannelMolecular PhysiologySignal TransductionBiochemistryFunctional Selectivity +9

Application of Barluenga Boronic Coupling (BBC) to the Parallel Synthesis of Drug‐like and Drug Fragment‐like Molecules

Shoko Nakagawa, Katie A. Bainbridge, Ken J. Butcher, +3

ChemMedChem

Quantitative UPLC-MS/MS analysis of the gut microbial co-metabolites phenylacetylglutamine, 4-cresyl sulphate and hippurate in human urine: INTERMAP Study

Anisha Wijeyesekera, Philip A. Clarke, Magda Bictash, +9

Analytical Methods

Identification of novel scaffolds targeting Mycobacterium tuberculosis

Michael Dal Molin, Petra Selchow, Daniel Schäfle, +4

Journal of Molecular Medicine

Pulmonary TuberculosisTuberculosis PreventionMycobacterium TuberculosisTuberculosisAntibacterial Agent +4

Dual NK1 antagonists—serotonin reuptake inhibitors as potential antidepressants. Part 2: SAR and activity of benzyloxyphenethyl piperazine derivatives

Thomas Ryckmans, Olivier Berton, R. Grimée, +5

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyBenzyloxyphenethyl Piperazine DerivativesPsychoactive DrugPsychiatryMedicine +9