Discovery of anti-inflammatory clinical candidate E6201, inspired from resorcylic lactone LL-Z1640-2, III

Palladium-catalyzed vinylic hydrogen substitution reactions with aryl, benzyl, and styryl halides

Richard F. Heck, J. P. Nolley · The Journal of Organic Chemistry · 1972 · 2.1K citations

Chemical Engineering, Cross-coupling Reaction, Engineering +12

Palladium-catalyzed synthesis of arylamines from aryl halides. Mechanistic studies lead to coupling in the absence of tin reagents

Janis Louie, John F. Hartwig · Tetrahedron Letters · 1995 · 877 citations · Full text

Asymmetric Catalysis, Chemical Engineering, Cross-coupling Reaction +13

THE FACILE SYNTHESIS OF LACTONES

Teruaki Mukaiyama, Masahiro Usui, Kazuhiko Saigo · Chemistry Letters · 1976 · 228 citations

Abstract Direct Lactonization, Engineering, ω-Hydroxy Acids +7

New zearalenone related macrolides and isocoumarins from an unidentified fungus

George A. Ellestad, F. M. Lovell, N. A. PERKINSON et al. · The Journal of Organic Chemistry · 1978 · 113 citations

Bioorganic Chemistry, Engineering, Altmetric Attention Score +17

E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities

Masaki Goto, Jesse C. Chow, Kenzo Muramoto et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 52 citations