Tomohiro Matsushima

Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage

Yuji Yamamoto, Junji Matsui, Tomohiro Matsushima et al. · Vascular Cell · 2014 · 478 citations · Full text

Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

Kiyoshi Okamoto, Megumi Ikemori‐Kawada, A. Jestel et al. · ACS Medicinal Chemistry Letters · 2014 · 263 citations · Full text

E7050: A dual c‐Met and VEGFR‐2 tyrosine kinase inhibitor promotes tumor regression and prolongs survival in mouse xenograft models

Takayuki Nakagawa, Osamu Tohyama, Atsumi Yamaguchi et al. · Cancer Science · 2009 · 103 citations · Full text

Mouse Xenograft Models, Chemoprevention Strategy, Cancer Biology +20

E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

Kazuhiko Yamada, Yusaku Hori, Satoshi Inoue et al. · Cancer Research · 2021 · 57 citations · Full text

Synthetic studies of 18-membered anti-tumor macrolide, tedanolide. Computer-aided conformational design of a seco-acid derivative for efficient macrolactonization

Tomohiro Matsushima, Kiyoshi Horita, Noriyuki Nakajima et al. · Tetrahedron Letters · 1996 · 47 citations

Engineering, Diversity-oriented Synthesis, Efficient Macrolactonization +8