Osamu Tohyama

Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane

Akihiro Imura, Akiko Iwano, Osamu Tohyama et al. · FEBS Letters · 2004 · 524 citations

Life Sciences, Biochemistry, Molecular Biology +8

Lenvatinib, an angiogenesis inhibitor targeting VEGFR/FGFR, shows broad antitumor activity in human tumor xenograft models associated with microvessel density and pericyte coverage

Yuji Yamamoto, Junji Matsui, Tomohiro Matsushima et al. · Vascular Cell · 2014 · 500 citations · Full text

Medicine, Oncology, Pharmacology +16

Antitumor Activity of Lenvatinib (E7080): An Angiogenesis Inhibitor That Targets Multiple Receptor Tyrosine Kinases in Preclinical Human Thyroid Cancer Models

Osamu Tohyama, Junji Matsui, Kotaro Kodama et al. · Journal of Thyroid Research · 2014 · 480 citations · Full text

Medicine, Oncology, Pharmacology +17

Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models

Yasuhiro Funahashi, Kiyoshi Okamoto, Yusuke Adachi et al. · Cancer Science · 2014 · 278 citations · Full text

Medicine, Oncology, Pharmacology +17

Klotho Is a Novel β-Glucuronidase Capable of Hydrolyzing Steroid β-Glucuronides

Osamu Tohyama, Akihiro Imura, Akiko Iwano et al. · Journal of Biological Chemistry · 2004 · 224 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +8