Secreted Klotho protein in sera and CSF: implication for post‐translational cleavage in release of Klotho protein from cell membrane

Akihiro Imura, Akiko Iwano, Osamu Tohyama, +5

FEBS Letters

Protein SecretionPost‐translational CleavageImmunologyCellular PhysiologyMembrane-bound Klotho Proteins +20

Establishment of sandwich ELISA for soluble alpha-Klotho measurement: Age-dependent change of soluble alpha-Klotho levels in healthy subjects

Y. Yamazaki, Akihiro Imura, Itaru Urakawa, +18

Biochemical and Biophysical Research Communications

AllergyHealthy SubjectsMedicineBioanalysisSandwich Elisa +3

α-Klotho as a Regulator of Calcium Homeostasis

Akihiro Imura, Yoshihito Tsuji, Miyahiko Murata, +10

Science

Homeostatic MechanismParathyroid GlandShort LifespanCellular PhysiologyOxidative Stress +18

Synthesis and hybridization studies on two complementary nona(2'-O-methyl)ribonucleotides

Hideo Inoue, Yoji Hayase, Akihiro Imura, +3

Nucleic Acids Research

Combinatorial ChemistryMedicinal ChemistryBioorganic ChemistryBiochemistryNatural Sciences +11

Cognition impairment in the genetic model of aging klotho gene mutant mice: a role of oxidative stress

Taku Nagai, Kiyofumi Yamada, Hyoung‐Chun Kim, +5

The FASEB Journal

AgingGeneticsOxidative StressAlzheimer's DiseaseGenetic Model +14

The human OX40/gp34 system directly mediates adhesion of activated T cells to vascular endothelial cells.

Akihiro Imura, Tomohide Hori, Kazunori Imada, +5

The Journal of Experimental Medicine

Cell AdhesionImmunologyBlood CellPathologyImmunoediting +19

A translocation causing increased α-Klotho level results in hypophosphatemic rickets and hyperparathyroidism

Catherine A. Brownstein, F.T. Adler, Carol Nelson‐Williams, +7

Proceedings of the National Academy of Sciences

Parathyroid DiseasePathologyα-Klotho Level ResultsParathyroid GlandOsteoporosis +17

Klotho Is a Novel β-Glucuronidase Capable of Hydrolyzing Steroid β-Glucuronides

Osamu Tohyama, Akihiro Imura, Akiko Iwano, +4

Journal of Biological Chemistry

Activation of OX40 Signal Transduction Pathways Leads to Tumor Necrosis Factor Receptor-associated Factor (TRAF) 2- and TRAF5-mediated NF-κB Activation

Shin Kawamata, Toshiyuki Hori, Akihiro Imura, +2

Journal of Biological Chemistry

Crystal Structures of Cyclohexanone Monooxygenase Reveal Complex Domain Movements and a Sliding Cofactor

I.A. Mirza, Brahm J. Yachnin, Shaozhao Wang, +6

Journal of the American Chemical Society