A. Jestel

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

Henry E. Pelish, Brian B. Liau, I Niţulescu et al. · Nature · 2015 · 391 citations · Full text

Mediator Kinase Inhibition, Transcriptional Regulation, Signal Transduction +5

Distinct Binding Mode of Multikinase Inhibitor Lenvatinib Revealed by Biochemical Characterization

Kiyoshi Okamoto, Megumi Ikemori‐Kawada, A. Jestel et al. · ACS Medicinal Chemistry Letters · 2014 · 263 citations · Full text

Structures, functions and adaptations of the human LINE-1 ORF2 protein

Eric T. Baldwin, Trevor van Eeuwen, David Hoyos et al. · Nature · 2023 · 107 citations · Full text

Crystal Structure of the Catalytic Domain of Human Atypical Protein Kinase C-iota Reveals Interaction Mode of Phosphorylation Site in Turn Motif

Albrecht Messerschmidt, Sofia Macieira, Milko Velarde et al. · Journal of Molecular Biology · 2005 · 98 citations

Crystal Structure, Catalytic Domain, Protein Function +10

(1<i>R</i>,2<i>R</i>)-<i>N</i>-(1-Cyanocyclopropyl)-2-(6-methoxy-1,3,4,5-tetrahydropyrido[4,3-<i>b</i>]indole-2-carbonyl)cyclohexanecarboxamide (AZD4996): A Potent and Highly Selective Cathepsin K Inhibitor for the Treatment of Osteoarthritis

Alexander G. Dossetter, Howard A. Beeley, Jonathan Bowyer et al. · Journal of Medicinal Chemistry · 2012 · 39 citations · Full text

Combinatorial Chemistry, Pharmaceutical Science, Bioorganic Chemistry +19