Use of Dynasore, the Small Molecule Inhibitor of Dynamin, in the Regulation of Endocytosis

Tomas Kirchhausen, Eric Macia, Henry E. Pelish

Methods in enzymology on CD-ROM/Methods in enzymology

Molecular PharmacologyCell SignalingMedicinePhysiologyEndocytic Pathway +7

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

Henry E. Pelish, Brian B. Liau, I Niţulescu, +23

Nature

Mediator Kinase InhibitionTranscriptional RegulationSignal TransductionSignaling PathwayCell Regulation +3

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics

Zachary C. Poss, Christopher C. Ebmeier, Aaron Odell, +7

Cell Reports

Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro

Henry E. Pelish, Jeffrey R. Peterson, Susana Salvarezza, +7

Nature Chemical Biology

Signal TransductionSignaling PathwayCell RegulationCell SignalingNatural Sciences +7

An Alkylsilyl-Tethered, High-Capacity Solid Support Amenable to Diversity-Oriented Synthesis for One-Bead, One-Stock Solution Chemical Genetics

John A. Tallarico, Kris M. Depew, Henry E. Pelish, +5

Journal of Combinatorial Chemistry

Supramolecular AssemblyEngineeringOrganic ChemistryChemistryDiversity Oriented Synthesis +14

Biochemical Suppression of Small-Molecule Inhibitors: A Strategy to Identify Inhibitor Targets and Signaling Pathway Components

Jeffrey R. Peterson, Andres M. Lebensohn, Henry E. Pelish, +1

Chemistry & Biology

Biochemical SuppressionSignaling Pathway ComponentsMedicinal ChemistryDrug TargetBiochemistry +11

Mediator Kinase Phosphorylation of STAT1 S727 Promotes Growth of Neoplasms With JAK-STAT Activation

I Niţulescu, Sara C. Meyer, Qiang Wen, +5

EBioMedicine

NVL-520 Is a Selective, TRK-Sparing, and Brain-Penetrant Inhibitor of ROS1 Fusions and Secondary Resistance Mutations

Alexander Drilon, Joshua C. Horan, Anupong Tangpeerachaikul, +20

Cancer Discovery

The Selectivity of Austocystin D Arises from Cell-Line-Specific Drug Activation by Cytochrome P450 Enzymes

Kevin M. Marks, Eun Sun Park, Alexander Arefolov, +6

Journal of Natural Products

NVL-655 Is a Selective and Brain-Penetrant Inhibitor of Diverse ALK-Mutant Oncoproteins, Including Lorlatinib-Resistant Compound Mutations

Joshua C. Horan, Anupong Tangpeerachaikul, Aurélie Swalduz, +24

Cancer Discovery