John A. Tallarico

Tankyrase inhibition stabilizes axin and antagonizes Wnt signalling

Shih-Min A. Huang, Yuji Mishina, Shanming Liu et al. · Nature · 2009 · 2.1K citations

Tankyrase Inhibition, Signal Transduction, Signaling Pathway +7

Selective VPS34 inhibitor blocks autophagy and uncovers a role for NCOA4 in ferritin degradation and iron homeostasis in vivo

William E. Dowdle, Beat Nyfeler, Jane Nagel et al. · Nature Cell Biology · 2014 · 715 citations

Inflammation, Cell Autophagy, Signal Transduction +13

Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

Konstantinos J. Mavrakis, E. Robert McDonald, Michael R. Schlabach et al. · Science · 2016 · 538 citations

SMN2 splice modulators enhance U1–pre-mRNA association and rescue SMA mice

James Palacino, Susanne E. Swalley, Cheng Song et al. · Nature Chemical Biology · 2015 · 422 citations

Transcriptional Regulation, Genetics, Gene Regulation +7

Harnessing the anti-cancer natural product nimbolide for targeted protein degradation

Jessica N. Spradlin, Xirui Hu, Carl C. Ward et al. · Nature Chemical Biology · 2019 · 404 citations

Drug Targeting, Health Sciences, Biochemistry +9