Concepedia

E6201 [(3S,4R,5Z,8S,9S,11E)-14-(Ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a Novel Kinase Inhibitor of Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase Kinase (MEK)-1 and MEK Kinase-1: In Vitro Characterization of Its Anti-Inflammatory and Antihyperproliferative Activities

Masaki Goto, Jesse C. Chow, Kenzo Muramoto, Kenichi Chiba, Satoshi Yamamoto, Masanori Fujita, Hiroshi Obaishi, Kenji Tai, Yoshiharu Mizui, Isao Tanaka,

Journal of Pharmacology and Experimental Therapeutics · 2009 · 53 citations · 31 references

DOI

Concepts

References

31

IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation

Frank Mercurio, Hengyi Zhu, Brion W. Murray et al. · Science · 1997 · 2K citations

, , +15

IκB Kinase-β: NF-κB Activation and Complex Formation with IκB Kinase-α and NIK

John Woronicz, Xiong Gao, Zhaodan Cao et al. · Science · 1997 · 1.2K citations

, , +16

Etanercept as Monotherapy in Patients with Psoriasis

Craig L. Leonardi, JEROLD L. POWERS, Robert Matheson et al. · New England Journal of Medicine · 2003 · 1.2K citations · Full text

, , +16

Efficacy and safety of infliximab monotherapy for plaque-type psoriasis: a randomised trial

Umesh Chaudhari, Pat Romano, LD Mulcahy et al. · The Lancet · 2001 · 904 citations

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Mineralocorticoid and Glucocorticoid Receptor Activities Distinguished by Nonreceptor Factors at a Composite Response Element

David Pearce, Keith R. Yamamoto · Science · 1993 · 458 citations

, , +13