Inflammasome Activation is an innate immune signaling process in which pattern-recognition receptor sensors, following a priming and subsequent danger-sensing step, oligomerize with adaptor and effector proteins to form multiprotein inflammasome complexes that activate inflammatory caspases, thereby processing pro–IL-1β and pro–IL-18 into their mature forms and inducing pyroptotic cell death.
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2017–2026
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8.2K
NF-κB signaling in inflammation
Ting Liu, Lingyun Zhang, Donghyun Joo et al. · Signal Transduction and Targeted Therapy · 2017 · 8.1K citations · Full text
Life Sciences, Immunology, Pathology +17
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
Jianjin Shi, Yue Zhao, Kun Wang et al. · Nature · 2015 · 6.5K citations
A role for mitochondria in NLRP3 inflammasome activation
Rongbin Zhou, Amir S. Yazdi, Philippe Menu et al. · Nature · 2010 · 5.4K citations
Gout-associated uric acid crystals activate the NALP3 inflammasome
Fabio Martinon, Virginie Pétrilli, Annick Mayor et al. · Nature · 2006 · 5.2K citations
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Peter Duewell, Hajime Kono, Katey J. Rayner et al. · Nature · 2010 · 3.9K citations · Full text
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- TKThirumala‐Devi Kanneganti
St. Jude Children's Research Hospital, United States
108 publications · 24.5K citations
74
h-index
- ELEicke Latz
University of Massachusetts Chan Medical School, United States
76 publications · 34.2K citations
55
h-index
- KAKatherine A. Fitzgerald
University of Massachusetts Chan Medical School, United States
63 publications · 36.7K citations
52
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- GN
47
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- JT
47
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1–5 of 47.8K
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5.1K
University of Massachusetts Chan Medical School
Worcester, United States
92 h-index
479 publications
221.5K citations
Harvard University
Cambridge, United States
92 h-index
746 publications
206.6K citations
St. Jude Children's Research Hospital
Memphis, United States
80 h-index
522 publications
122.7K citations
University of Lausanne
Lausanne, Switzerland
75 h-index
348 publications
177.2K citations
Yale University
New Haven, United States
74 h-index
582 publications
164.9K citations
Inserm
Paris, France
74 h-index
924 publications
122.1K citations
University of Michigan
Ann Arbor, United States
74 h-index
381 publications
121.5K citations
National Institutes of Health
Bethesda, United States
73 h-index
655 publications
138.9K citations
1–8 of 5.1K
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- The Journal of Immunology
JI · 277 publications · 38.6K citations
117
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- Proceedings of the National Academy of Sciences
PNAS · 119 publications · 26.9K citations
84
h-index
- Nature Communications
129 publications · 21.7K citations
83
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- Journal of Biological Chemistry
JBC · 150 publications · 20.6K citations
77
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- Immunity
78 publications · 32.9K citations
73
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