Concepedia

Caspase-4 Activation

Caspase-4 Activation is a molecular signaling event belonging to the class of inflammasome activation pathways, distinguished by the specific proteolytic auto-activation of caspase-4 in response to cytosolic lipopolysaccharide, leading to pyroptotic cell death and interleukin-1β processing in human innate immunity.

313

Publications

19.5K

Citations

2.1K

Authors

705

Institutions

Publications per year

2017–2026

116

Parents

Publications

313

Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Aβ-induced cell death

Junichi Hitomi, Taiichi Katayama, Yutaka Eguchi et al. · The Journal of Cell Biology · 2004 · 829 citations · Full text

, , +17

Pivotal Role of TLR4 Receptors in Alcohol-Induced Neuroinflammation and Brain Damage

Silvia Alfonso‐Loeches, María Pascual‐Lucas, Ana María Andrés Blanco et al. · Journal of Neuroscience · 2010 · 581 citations · Full text

, , +15

Noncanonical Inflammasome Activation of Caspase-4/Caspase-11 Mediates Epithelial Defenses against Enteric Bacterial Pathogens

Leigh A. Knodler, Shauna M. Crowley, Ho Pan Sham et al. · Cell Host & Microbe · 2014 · 440 citations

, , +17

Human CARD4 Protein Is a Novel CED-4/Apaf-1 Cell Death Family Member That Activates NF-κB

John Bertin, Waan-Jeng Nir, Colleen M. Fischer et al. · Journal of Biological Chemistry · 1999 · 364 citations · Full text

, , +16

Astrocytes Secrete Exosomes Enriched with Proapoptotic Ceramide and Prostate Apoptosis Response 4 (PAR-4)

Guanghu Wang, Michael B. Dinkins, Qian He et al. · Journal of Biological Chemistry · 2012 · 358 citations · Full text

, , +17

1–5 of 313

Authors

2.1K

  1. AR
    Avinash R. Shenoy

    Imperial College London, United Kingdom

    4 publications · 392 citations

    4

    h-index

  2. CC
    Chen Chen Jiang

    University of Newcastle Australia, Australia

    4 publications · 282 citations

    4

    h-index

  3. PH
    Peter Hersey

    The University of Sydney, Australia

    4 publications · 282 citations

    4

    h-index

  4. XD
    Xu Dong Zhang

    University of Newcastle Australia, Australia

    4 publications · 282 citations

    4

    h-index

  5. MP
    Mark P. Mattson

    National Institute on Aging, United States

    4 publications · 344 citations

    4

    h-index

1–5 of 2.1K

Institutions

705

  1. Harvard University

    Cambridge, United States

    10 h-index

    34 publications

    2.3K citations

  2. University of Michigan

    Ann Arbor, United States

    8 h-index

    18 publications

    876 citations

  3. The University of Osaka

    Osaka, Japan

    8 h-index

    37 publications

    10.5K citations

  4. Inserm

    Paris, France

    7 h-index

    38 publications

    4.9K citations

  5. Massachusetts General Hospital

    Boston, United States

    6 h-index

    33 publications

    1.9K citations

  6. The University of Texas MD Anderson Cancer Center

    Houston, United States

    6 h-index

    17 publications

    2.6K citations

  7. University of Kentucky

    Lexington, United States

    6 h-index

    16 publications

    1.1K citations

  8. Centre National de la Recherche Scientifique

    Paris, France

    5 h-index

    26 publications

    3.6K citations

1–8 of 705

Venues

  1. PubMed

    Repository · 17 publications · 818 citations

    14

    h-index

  2. Journal of Biological Chemistry

    JBC · 13 publications · 1.4K citations

    11

    h-index

  3. Scientific Reports

    9 publications · 341 citations

    9

    h-index

  4. PLoS ONE

    9 publications · 470 citations

    9

    h-index

  5. The Journal of Immunology

    JI · 6 publications · 483 citations

    6

    h-index

1–5