Concepedia

Potent BRAF kinase inhibitors based on 2,4,5-trisubstituted imidazole with naphthyl and benzothiophene 4-substituents

Dan Niculescu‐Duvaz, Ion Niculescu‐Duvaz, Bart M. J. M. Suijkerbuijk, Delphine Ménard, Alfonso Zambon, Lawrence Davies, Jean‐François Pons, Steven R. Whittaker, Richard Marais, Caroline J. Springer

Bioorganic & Medicinal Chemistry · 2013 · 42 citations · 21 references

DOIFull text

Open access

Concepts

References

21

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

, , +12

Improved Survival with Vemurafenib in Melanoma with BRAF V600E Mutation

Paul B. Chapman, Axel Hauschild, Caroline Robert et al. · New England Journal of Medicine · 2011 · 7.7K citations · Full text

, , +9

Mechanism of Activation of the RAF-ERK Signaling Pathway by Oncogenic Mutations of B-RAF

Paul Wan, Mathew J. Garnett, S. Mark Roe et al. · Cell · 2004 · 2.8K citations · Full text

, , +14

Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma

Gideon Bollag, Peter Hirth, James Tsai et al. · Nature · 2010 · 1.8K citations

, , +14

RG7204 (PLX4032), a Selective BRAFV600E Inhibitor, Displays Potent Antitumor Activity in Preclinical Melanoma Models

Hong Yang, Brian Higgins, Kenneth Kolinsky et al. · Cancer Research · 2010 · 405 citations

, , +16