A Major Role for TPPII in Trimming Proteasomal Degradation Products for MHC Class I Antigen Presentation

A System for Stable Expression of Short Interfering RNAs in Mammalian Cells

Thijn R. Brummelkamp, René Bernards, Reuven Agami · Science · 2002 · 4.3K citations · Full text

Functional Genomics, Psuper Vector, Short Interfering Rnas +15

Inhibitors of the proteasome block the degradation of most cell proteins and the generation of peptides presented on MHC class I molecules

Kenneth L. Rock, Colette F. Gramm, Lisa Rothstein et al. · Cell · 1994 · 2.5K citations

Proteasome Block, Biochemistry, Mhc Class +13

Rapid degradation of a large fraction of newly synthesized proteins by proteasomes

Ulrich S. Schubert, Luis C. Antón, James S. Gibbs et al. · Nature · 2000 · 1.5K citations

Protein Chemistry, Biochemistry, Protein Folding +10

ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum

Thomas Serwold, Federico Gonzãlez, Jennifer Kim et al. · Nature · 2002 · 615 citations

Protein Function, Signal Transduction, Mhc Class +12

The Sizes of Peptides Generated from Protein by Mammalian 26 and 20 S Proteasomes

Alexei F. Kisselev, Tatos Akopian, Kee Min Woo et al. · Journal of Biological Chemistry · 1999 · 571 citations · Full text