Concepedia

Major Histocompatibility Complex

Major Histocompatibility Complex is a multigene region of the vertebrate genome comprising tightly linked, highly polymorphic loci that encode cell-surface glycoproteins responsible for binding and presenting peptide antigens to T lymphocytes, thereby determining self–nonself recognition, shaping adaptive immune responses, and governing histocompatibility in transplantation.

28.8K

Publications

1.9M

Citations

86K

Authors

8.4K

Institutions

Publications per year

2017–2026

2.3K

Variants

Mhc

Parents

Children

Publications

28.8K

Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.

Kensuke Inaba, Muneo Inaba, Nikolaus Romani et al. · The Journal of Experimental Medicine · 1992 · 3.8K citations · Full text

, , +12

A novel MHC class I–like gene is mutated in patients with hereditary haemochromatosis

John N. Feder, Andreas Gnirke, Zenta Tsuchihashi et al. · Nature Genetics · 1996 · 3.7K citations

, , +12

Phenotypic Analysis of Antigen-Specific T Lymphocytes

John D. Altman, Paul Moss, Philip Goulder et al. · Science · 1996 · 3.6K citations

, , +17

Structure of the human class I histocompatibility antigen, HLA-A2

Pamela J. Björkman, Mark A. Saper, Boudjéma Samraoui et al. · Nature · 1987 · 3.5K citations

, , +12

Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules

Kirsten Falk, Olaf Rötzschke, Stefan Stevanovié et al. · Nature · 1991 · 2.4K citations

, , +14

1–5 of 28.8K

Authors

86K

  1. PP
    Peter Parham

    Stanford University, United States

    240 publications · 30.2K citations

    91

    h-index

  2. AS
    Alessandro Sette

    La Jolla Institute for Immunology, United States

    213 publications · 31.6K citations

    91

    h-index

  3. JL
    Jack L. Strominger

    Harvard University, United States

    204 publications · 33.1K citations

    82

    h-index

  4. JS
    John Sidney

    La Jolla Institute for Immunology, United States

    146 publications · 18.8K citations

    73

    h-index

  5. JT
    John Trowsdale

    University of Cambridge, United Kingdom

    152 publications · 19.7K citations

    69

    h-index

1–5 of 86K

Institutions

8.4K

  1. Howard Hughes Medical Institute

    Chevy Chase, United States

    176 h-index

    2.2K publications

    363.4K citations

  2. Harvard University

    Cambridge, United States

    162 h-index

    4.4K publications

    504.1K citations

  3. National Institutes of Health

    Bethesda, United States

    136 h-index

    3.1K publications

    278.3K citations

  4. Stanford University

    Stanford, United States

    129 h-index

    2.6K publications

    283.5K citations

  5. Inserm

    Paris, France

    121 h-index

    3.6K publications

    271.3K citations

  6. University of Oxford

    Oxford, United Kingdom

    120 h-index

    1.9K publications

    179.6K citations

  7. National Cancer Institute

    Bethesda, United States

    114 h-index

    1.9K publications

    195.9K citations

  8. University of Washington

    Seattle, United States

    105 h-index

    1.4K publications

    126K citations

1–8 of 8.4K

Venues

  1. The Journal of Experimental Medicine

    1.3K publications · 153.6K citations

    196

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 1.3K publications · 141.5K citations

    184

    h-index

  3. Nature

    427 publications · 111.7K citations

    182

    h-index

  4. The Journal of Immunology

    JI · 2.9K publications · 173.8K citations

    163

    h-index

  5. Science

    262 publications · 78.5K citations

    152

    h-index

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