Concepedia

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz, Martin L. Neitzel, Gary D. Probst, Roy K. Hom, Brian Peterson, Robert A. Galemmo, Andrei W. Konradi, Hing L. Sham,

Bioorganic & Medicinal Chemistry Letters · 2011 · 38 citations · 24 references

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JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain

Benoit Dérijard, Masahiko Hibi, I‐Huan Wu et al. · Cell · 1994 · 3.2K citations

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Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science · 2000 · 2.9K citations

ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume et al. · Genes & Development · 2002 · 1.3K citations · Full text

Absence of excitotoxicity-induced apoptosis in the hippocampus of mice lacking the Jnk3 gene

Derek Yang, Chia‐Yi Kuan, Alan J. Whitmarsh et al. · Nature · 1997 · 1.2K citations

, , +11

Cardiotoxicity of the cancer therapeutic agent imatinib mesylate

Risto Kerkelä, Luanda Grazette, Rinat Yacobi et al. · Nature Medicine · 2006 · 1.2K citations

, , +4