Brian Peterson

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7

Design and synthesis of a novel, orally active, brain penetrant, tri-substituted thiophene based JNK inhibitor

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 38 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Discovery of (<i>R</i>)-4-Cyclopropyl-7,8-difluoro-5-(4-(trifluoromethyl)phenylsulfonyl)-4,5-dihydro-1<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND006) and (<i>R</i>)-4-Cyclopropyl-8-fluoro-5-(6-(trifluoromethyl)pyridin-3-ylsulfonyl)-4,5-dihydro-2<i>H</i>-pyrazolo[4,3-<i>c</i>]quinoline (ELND007): Metabolically Stable γ-Secretase Inhibitors that Selectively Inhibit the Production of Amyloid-β over Notch

Gary D. Probst, Danielle L. Aubele, Simeon Bowers et al. · Journal of Medicinal Chemistry · 2013 · 32 citations

Pharmacy, Medicinal Chemistry, Pharmacology +12

Design and synthesis of brain penetrant selective JNK inhibitors with improved pharmacokinetic properties for the prevention of neurodegeneration

Simeon Bowers, Anh P. Truong, R. Jeffrey Neitz et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 32 citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +12

Discovery, Optimization, and Pharmacological Characterization of Novel Heteroaroylphenylureas Antagonists of C−C Chemokine Ligand 2 Function

Edgardo Laborde, Robert W. Macsata, Fanying Meng et al. · Journal of Medicinal Chemistry · 2011 · 23 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +17