Simeon Bowers

Antibody–Drug Conjugates (ADCs) Derived from Interchain Cysteine Cross-Linking Demonstrate Improved Homogeneity and Other Pharmacological Properties over Conventional Heterogeneous ADCs

Christopher R. Behrens, Edward Ha, Lawrence Chinn et al. · Molecular Pharmaceutics · 2015 · 153 citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Required Immunoproteasome Subunit Inhibition Profile for Anti-Inflammatory Efficacy and Clinical Candidate KZR-616 ((2<i>S</i>,3<i>R</i>)-<i>N</i>-((<i>S</i>)-3-(Cyclopent-1-en-1-yl)-1-((<i>R</i>)-2-methyloxiran-2-yl)-1-oxopropan-2-yl)-3-hydroxy-3-(4-methoxyphenyl)-2-((<i>S</i>)-2-(2-morpholinoacetamido)propanamido)propenamide)

Henry W. B. Johnson, Eric Lowe, Janet L. Anderl et al. · Journal of Medicinal Chemistry · 2018 · 100 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +11

Trityl ethers in oligosaccharide synthesis: A novel strategy for the convergent assembly of oligosaccharides

Geert‐Jan Boons, Simeon Bowers, Diane M. Coe · Tetrahedron Letters · 1997 · 49 citations

Life Sciences, Biochemistry, Chemistry +13

Selective and Brain‐Permeable Polo‐like Kinase‐2 (Plk‐2) Inhibitors That Reduce α‐Synuclein Phosphorylation in Rat Brain

Danielle L. Aubele, Roy K. Hom, Marc Adler et al. · ChemMedChem · 2013 · 49 citations

Life Sciences, Medicinal Chemistry, Pharmacology +12

Design of an orally efficacious hydroxyethylamine (HEA) BACE-1 inhibitor in a preclinical animal model

Anh P. Truong, G. Toth, Gary D. Probst et al. · Bioorganic & Medicinal Chemistry Letters · 2010 · 48 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +7