ASK1 is essential for endoplasmic reticulum stress-induced neuronal cell death triggered by expanded polyglutamine repeats

Hideki Nishitoh, Atsushi Matsuzawa, Kei Tobiume, +6

Genes & Development

ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis

Kei Tobiume, Atsushi Matsuzawa, Takumi Takahashi, +7

EMBO Reports

Signal TransductionSignaling PathwayCell RegulationJnk/p38 Map KinasesApoptosis +9

p53 regulates glucose metabolism through an IKK-NF-κB pathway and inhibits cell transformation

Keiko Kawauchi, Keigo Araki, Kei Tobiume, +1

Nature Cell Biology

Systems BiologyP53 RegulatesIkk-nf-κb PathwayMolecular PathwayMedicine +8

Activation of apoptosis signal‐regulating kinase 1 by the stress‐induced activating phosphorylation of pre‐formed oligomer

Kei Tobiume, Masao Saitoh, Hidenori Ichijo

Journal of Cellular Physiology

Loss of p53 enhances catalytic activity of IKKβ through O-linked β-N-acetyl glucosamine modification

Keiko Kawauchi, Keigo Araki, Kei Tobiume, +1

Proceedings of the National Academy of Sciences

Metabolic RemodelingChemical BiologyCellular PhysiologyTumor BiologyPositive Feedback Loop +16

Involvement of ASK1 in Ca ²⁺ ‐induced p38 MAP kinase activation

Kohsuke Takeda, Atsushi Matsuzawa, Hideki Nishitoh, +5

EMBO Reports

A role for Id in the regulation of TGF-β-induced epithelial–mesenchymal transdifferentiation

Masayuki Kondo, Eva Cubillo, Kei Tobiume, +8

Cell Death and Differentiation

Tgf-β-induced Epithelial–mesenchymal TransdifferentiationEpithelial-mesenchymal TransitionDevelopmental BiologySignal TransductionSignaling Pathway +8

Hedgehog signaling overrides p53-mediated tumor suppression by activating Mdm2

Yoshinori Abe, Eri Oda-Sato, Kei Tobiume, +5

Proceedings of the National Academy of Sciences

Developmental BiologyP53 UbiquitinationSignaling PathwayCell SignalingMedicine +8

ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis

Takayuki Iriyama, Kohsuke Takeda, Hiromi Nakamura, +21

The EMBO Journal

InflammationTumor BiologyCell RegulationMedicineApoptosis +7

Apoptosis Signal-regulating Kinase (ASK) 2 Functions as a Mitogen-activated Protein Kinase Kinase Kinase in a Heteromeric Complex with ASK1

Kohsuke Takeda, Rieko Shimozono, Takuya Noguchi, +7

Journal of Biological Chemistry

ApoptosisImmunologyCell DeathFunctional Map3k ComplexCellular Physiology +17