E-ring-modified 7-oxyiminomethyl camptothecins: Synthesis and preliminary in vitro and in vivo biological evaluation

Modification of the hydroxylactone ring of camptothecin: inhibition of mammalian topoisomerase I and biological activity

Robert Hertzberg, Mary Jo Caranfa, Kenneth G. Holden et al. · Journal of Medicinal Chemistry · 1989 · 414 citations

Medicine, Medicinal Chemistry, Pharmacology +12

Novel 7-Oxyiminomethyl Derivatives of Camptothecin with Potent in Vitro and in Vivo Antitumor Activity

Sabrina Dallavalle, Anna Maria Ferrari, Barbara Biasotti et al. · Journal of Medicinal Chemistry · 2001 · 103 citations

Medicine, Medicinal Chemistry, Pharmacology +14

BN 80245: An E-ring modified camptothecin with potent antiproliferative and topoisomerase I inhibitory activities

Olivier Lavergne, Laurence Lesueur‐Ginot, Francesc Pla Rodas et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 97 citations

Pharmacy, Medicinal Chemistry, Pharmacology +10

ABCG2 Mediates Differential Resistance to SN-38 (7-Ethyl-10-hydroxycamptothecin) and Homocamptothecins

Susan E. Bates, W Y Medina-Pérez, Glenda Kohlhagen et al. · Journal of Pharmacology and Experimental Therapeutics · 2004 · 95 citations

Medicine, Oncology, Pharmacology +12

A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone-selected colon carcinoma cell line.

Paola Perego, Michelandrea De Cesare, P De Isabella et al. · PubMed · 2001 · 83 citations

Medicine, Oncology, Pharmacology +14