Concepedia

Pdro, a Protein Associated with Late Endosomes and Lysosomes and Implicated in Cellular Cholesterol Homeostasis

P. Guillaumot, Céline Luquain, Mouhannad Malek, Anne‐Laure Huber, Sabine Brugière, Jérôme Garin, Didier Grünwald, Régnier Daniel, Virginie Pétrilli, Étienne Lefai,

PLoS ONE · 2010 · 23 citations · 31 references

DOIFull text

Open access

Abstract

LDL-derived cholesterol release involves LE/LY motility that is linked to actin dynamics. Because Pdro regulates these two processes, we propose that modulation of Pdro expression in response to sterol levels regulates LDL-derived cholesterol through both LDL uptake and LE/LY dynamics, to ultimately control free cholesterol homeostasis.

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