Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects

Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain

Raimond B. G. Ravelli, Benoı̂t Gigant, Patrick A. Curmi et al. · Nature · 2004 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +14

Isolation and structure of the strong cell growth and tubulin inhibitor combretastatin A-4

George R. Pettit, Sheo B. Singh, Ernest Hamel et al. · Cellular and Molecular Life Sciences · 1989 · 789 citations

Life Sciences, Biochemistry, Cell Biology +11

Potent, Orally Active Heterocycle-Based Combretastatin A-4 Analogues:  Synthesis, Structure−Activity Relationship, Pharmacokinetics, and In Vivo Antitumor Activity Evaluation

Le Wang, Keith W. Woods, Qun Li et al. · Journal of Medicinal Chemistry · 2002 · 421 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +14

Discovery of 1-(4-Fluorophenyl)-(3<i>R</i>)-[3-(4-fluorophenyl)-(3<i>S</i>)- hydroxypropyl]-(4<i>S</i>)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Stuart B. Rosenblum, Tram Huynh, Adriano Afonso et al. · Journal of Medicinal Chemistry · 1998 · 355 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11

Synthesis and evaluation of stilbene and dihydrostilbene derivatives as potential anticancer agents that inhibit tubulin polymerization

Mark Cushman, Dhanapalan Nagarathnam, Dhanushya Gopal et al. · Journal of Medicinal Chemistry · 1991 · 299 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +9