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Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects

Medicinal ChemistryBiochemistryAntiproliferative ActivityNatural SciencesMedicineRational Drug DesignLead IdentificationTubulin Targeting EffectsDrug DevelopmentChemical BiologyPharmacologyMolecular ModelingPharmaceutical ChemistryDrug Discovery