Discovery of 1-(4-Fluorophenyl)-(3<i>R</i>)-[3-(4-fluorophenyl)-(3<i>S</i>)- hydroxypropyl]-(4<i>S</i>)-(4-hydroxyphenyl)-2-azetidinone (SCH 58235):  A Designed, Potent, Orally Active Inhibitor of Cholesterol Absorption

Stuart B. Rosenblum, Tram Huynh, Adriano Afonso, +4

Journal of Medicinal Chemistry

Serum Total CholesterolPharmaceutical SciencePharmacotherapyPharmaceutical ChemistryMolecular Pharmacology +16

Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1)

Ashok V. Purandare, Zhong Chen, Tram Huynh, +7

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryMedicineMechanism Of ActionPyrazole InhibitorsPharmacotherapy +3

Optimization of pyrazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)

Tram Huynh, Zhong Chen, Suhong Pang, +14

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryMedicineNatural SciencesRational Drug Design +8

Benzo[d]imidazole inhibitors of Coactivator Associated Arginine Methyltransferase 1 (CARM1)—Hit to Lead studies

Honghe Wan, Tram Huynh, Suhong Pang, +8

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinal ChemistryBioorganic ChemistryBiochemistryMedicine +9

Identification of purine inhibitors of phosphodiesterase 7 (PDE7)

William J. Pitts, Wayne Vaccaro, Tram Huynh, +12

Bioorganic & Medicinal Chemistry Letters

Purine InhibitorsBiochemistryAntiparasitic AgentMedicineMechanism Of Action +3

Inhibitors of human mitotic kinesin Eg5: Characterization of the 4-phenyl-tetrahydroisoquinoline lead series

Christine M. Tarby, Robert F. Kaltenbach, Tram Huynh, +16

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryBiochemistryNatural Sciences4-Phenyl-tetrahydroisoquinoline Lead SeriesMedicine +6

Synthesis of 3-Arylpropenyl, 3-Arylpropynyl and 3-Arylpropyl 2-Azetidinones as Cholesterol Absorption Inhibitors: Application of the Palladium-Catalyzed Arylation of Alkenes and Alkynes

Stuart B. Rosenblum, Tram Huynh, Adriano Afonso, +1

Tetrahedron

DerivativesEngineeringCholesterol Absorption Inhibitors3-Arylpropyl 2-AzetidinonesOrganic Chemistry +7

Dihydropyrazolopyrimidines containing benzimidazoles as KV1.5 potassium channel antagonists

John Lloyd, Heather J. Finlay, Karnail S. Atwal, +12

Bioorganic & Medicinal Chemistry Letters

Molecular PharmacologyMedicinePharmacological AgentPharmacotherapyPharmacology +1

Discovery and Preclinical Pharmacology of an Oral Bromodomain and Extra-Terminal (BET) Inhibitor Using Scaffold-Hopping and Structure-Guided Drug Design

Ashvinikumar V. Gavai, Derek Norris, George V. Delucca, +42

Journal of Medicinal Chemistry

Dimethyl-diphenyl-propanamide Derivatives As Nonsteroidal Dissociated Glucocorticoid Receptor Agonists

Bingwei Yang, David S. Weinstein, Lidia M. Doweyko, +16

Journal of Medicinal Chemistry

Sar ExplorationMedicinal ChemistryBiochemistryFunctional SelectivityMedicine +12