Measurement Science and Technology · 2010 · 43 citations · 8 references
EngineeringBiotechnologyMetrologyNanotechnologyOpticsDimensional MetrologyNanomaterial CharacterizationNanoscale MaterialsOptical MetrologyBright-field ImagingBright-field MicroscopyDefect AnalysisMicroscopyNano-metrologyNanometer-scale ImagingNanometer-scale MetrologyNanometrology
We present an initial review of a novel through-focus scanning optical microscopy (TSOM pronounced as 'tee-som') imaging method that produces nanometer-dimensional measurement sensitivity using a conventional bright-field optical microscope. In the TSOM method a target is scanned through the focus of an optical microscope, acquiring conventional optical images at different focal positions. The TSOM images are constructed using the through-focus optical images. A TSOM image is unique under given experimental conditions and is sensitive to changes in the dimensions of a target in a distinct way. We use this characteristic for nanoscale-dimensional metrology. This technique can be used to identify the dimension which is changing between two nanosized targets and to determine the dimensions using a library-matching method. This methodology has potential utility for a wide range of target geometries and application areas, including nanometrology, nanomanufacturing, defect analysis, inspection, process control and biotechnology.
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Applications of nanoparticles in biology and medicine
OV Salata · Journal of Nanobiotechnology · 2004 · 2.3K citations · Full text
Life Sciences, Biomedical Engineering, Materials Science +17