Sulfonylureido thiazoles as fructose-1,6-bisphosphatase inhibitors for the treatment of Type-2 diabetes

Increased rate of gluconeogenesis in type II diabetes mellitus. A 13C nuclear magnetic resonance study.

I Magnusson, Douglas L. Rothman, Lee D. Katz et al. · Journal of Clinical Investigation · 1992 · 761 citations · Full text

Life Sciences, Endocrinology, Physiology +15

MB06322 (CS-917): A potent and selective inhibitor of fructose 1,6-bisphosphatase for controlling gluconeogenesis in type 2 diabetes

Mark D. Erion, Paul D. van Poelje, Qun Dang et al. · Proceedings of the National Academy of Sciences · 2005 · 162 citations

Life Sciences, Biochemistry, Pharmacology +17

Anilinoquinazoline Inhibitors of Fructose 1,6-Bisphosphatase Bind at a Novel Allosteric Site:  Synthesis, In Vitro Characterization, and X-ray Crystallography

Stephen W. Wright, Anthony Carlo, Maynard D. Carty et al. · Journal of Medicinal Chemistry · 2002 · 82 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

Benzoxazole benzenesulfonamides are novel allosteric inhibitors of fructose-1,6-bisphosphatase with a distinct binding mode

Thomas W von Geldern, Chunqiu Lai, Rebecca J. Gum et al. · Bioorganic & Medicinal Chemistry Letters · 2006 · 56 citations

Life Sciences, Biochemistry, Medicinal Chemistry +16

Stereoselective synthesis and biological activity of .beta.- and .alpha.-D-arabinose 1,5-diphosphate: analogs of a potent metabolic regulator

Bruce E. Maryanoff, Allen B. Reitz, Gene F. Tutwiler et al. · Journal of the American Chemical Society · 1984 · 38 citations

Life Sciences, Biochemistry, Cellular Metabolism +8