A general protocol for the generation of Nanobodies for structural biology

Els Pardon, Toon Laeremans, Sarah Triest, +7

Nature Protocols

NanoarchitectonicsGeneral ProtocolEngineeringBottom-up SynthesisNanomaterials +9

Unique carbohydrate–carbohydrate interactions are required for high affinity binding between FcγRIII and antibodies lacking core fucose

Claudia Ferrara, Sandra Grau, Christiane Jäger, +9

Proceedings of the National Academy of Sciences

GlycobiologyImmunologyImmunotherapeuticsAnalytical UltracentrifugationImmune System +18

Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase

Ralf Thoma, Tanja Schulz‐Gasch, Brigitte D’Arcy, +6

Nature

BiosynthesisBioorganic ChemistryAldo-keto ReductaseBiochemistryHuman Oxidosqualene Cyclase +11

Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV

Ralf Thoma, Bernd Löffler, M. Stihle, +3

Structure

BiochemistryProtein FoldingNatural SciencesPeptoidProline-specific Exopeptidase Activity +6

Inhibitor and NAD⁺ Binding to Poly(ADP-ribose) Polymerase As Derived from Crystal Structures and Homology Modeling^,

A. Ruf, Gilbert de Murcia, Georg E. Schulz

Biochemistry

Structure of the Acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1

Roger Dawson, Jörg Benz, Peter Stohler, +10

Nature Communications

The mechanism of the elongation and branching reaction of Poly(ADP-ribose) polymerase as derived from crystal structures and mutagenesis

A. Ruf, Véronique Rolli, Gilbert de Murcia, +1

Journal of Molecular Biology

BiochemistryNatural SciencesMolecular BiologyCrystal StructuresPolymer Reaction +1

A Novel Partial Agonist of Peroxisome Proliferator-Activated Receptor-γ (PPARγ) Recruits PPARγ-Coactivator-1α, Prevents Triglyceride Accumulation, and Potentiates Insulin Signaling in Vitro

Elke Burgermeister, Astride Schnoebelen, Angele Flament, +11

Molecular Endocrinology

Novel Partial AgonistInsulin SignalingMolecular PharmacologyMetabolic SyndromeSelective Ppargamma Modulators +18

Molecular Switch in the Glucocorticoid Receptor: Active and Passive Antagonist Conformations

G. Schoch, Brigitte D’Arcy, M. Stihle, +5

Journal of Molecular Biology

Signal TransductionMolecular PhysiologyBiochemistryPassive Antagonist ConformationsMedicine +12

Aleglitazar, a new, potent, and balanced dual PPARα/γ agonist for the treatment of type II diabetes

Agnès Bénardeau, Jörg Benz, Alfred Binggeli, +12

Bioorganic & Medicinal Chemistry Letters

Diabetes ManagementMedicineDiabetesPharmacological AgentPharmacotherapy +5