Wolfgang Haap

Systematic Investigation of Halogen Bonding in Protein–Ligand Interactions

Leo A. Hardegger, Bernd Kuhn, Beat Spinnler et al. · Angewandte Chemie International Edition · 2010 · 480 citations

Chemical Biology, Halogen Bonding, Biochemistry +10

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Leo A. Hardegger, Bernd Kuhn, Beat Spinnler et al. · ChemMedChem · 2011 · 128 citations

A Real-World Perspective on Molecular Design

Bernd Kuhn, Wolfgang Guba, Jérôme Hert et al. · Journal of Medicinal Chemistry · 2016 · 119 citations · Full text

Drug Target, Hit Identification, Molecular Biology +20

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming

Khader Valli Rupanagudi, Onkar P. Kulkarni, Julia Lichtnekert et al. · Annals of the Rheumatic Diseases · 2013 · 106 citations

Increased cathepsin S in Prdm1−/− dendritic cells alters the TFH cell repertoire and contributes to lupus

Sun Jung Kim, Sebastian Schätzle, Sohail Ahmed et al. · Nature Immunology · 2017 · 95 citations

Immune Regulation, Immunology, Immune System +16