Rational assignment of key motifs for function guides in silico enzyme identification

Matthias Höhne, Sebastian Schätzle, Helge Jochens, +2

Nature Chemical Biology

Sequence MotifKey MotifsFunctional GenomicsBiochemistrySilico Enzyme Identification +12

Rapid and Sensitive Kinetic Assay for Characterization of ω-Transaminases

Sebastian Schätzle, Matthias Höhne, Erik Redestad, +2

Analytical Chemistry

EngineeringEnzymatic ModificationBiosynthesisBioanalysisBiochemical Engineering +15

Potent and broad HIV-neutralizing antibodies in memory B cells and plasma

LaTonya D. Williams, Gilad Ofek, Sebastian Schätzle, +38

Science Immunology

Immunological MemoryMemory B CellHuman RetrovirusHumoral ResponseImmunology +13

Enzymatic Asymmetric Synthesis of Enantiomerically Pure Aliphatic, Aromatic and Arylaliphatic Amines with (<i>R</i>)‐Selective Amine Transaminases

Sebastian Schätzle, Fabian Steffen‐Munsberg, Ahmad Thontowi, +3

Advanced Synthesis & Catalysis

EngineeringAmine TransaminasesEnantiomerically Pure AliphaticEscherichia ColiOrganic Chemistry +16

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

Shelly J. Krebs, Young Do Kwon, Chaim A. Schramm, +58

Immunity

Primary ImmunodeficiencyHuman RetrovirusImmunologyAntiviral ResponseVirology +7

Discovery and Protein Engineering of Biocatalysts for Organic Synthesis

Geoffrey A. Behrens, Anke Hummel, Santosh Kumar Padhi, +2

Advanced Synthesis & Catalysis

BiosynthesisEnzymologyEngineeringBiochemistryEnzymes +13

Revealing the Structural Basis of Promiscuous Amine Transaminase Activity

Fabian Steffen‐Munsberg, Clare Vickers, Ahmad Thontowi, +7

ChemCatChem

Protein ChemistryBiochemistryNatural SciencesEnzyme CatalysisProtein Biosynthesis +11

Increased cathepsin S in Prdm1−/− dendritic cells alters the TFH cell repertoire and contributes to lupus

Sun Jung Kim, Sebastian Schätzle, Sohail Ahmed, +5

Nature Immunology

Immune RegulationImmunologyImmune SystemPrdm1−/− Dendritic CellsImmune Dysregulation +14

Connecting Unexplored Protein Crystal Structures to Enzymatic Function

Fabian Steffen‐Munsberg, Clare Vickers, Ahmad Thontowi, +7

ChemCatChem

Chiral AminesMedicinal ChemistryBiosynthesisBioorganic ChemistryEnantioselective Synthesis +13

Cloning and functional expression of a nitrile hydratase (NHase) from Rhodococcus equi TG328-2 in Escherichia coli, its purification and biochemical characterisation

Kamila Rzeznicka, Sebastian Schätzle, Dominique Böttcher, +2

Applied Microbiology and Biotechnology

BiosynthesisBiochemistryReactive Nitrogen SpecieEnzyme CatalysisEscherichia Coli +4