Leo A. Hardegger

Systematic Investigation of Halogen Bonding in Protein–Ligand Interactions

Leo A. Hardegger, Bernd Kuhn, Beat Spinnler et al. · Angewandte Chemie International Edition · 2010 · 480 citations

Chemical Biology, Halogen Bonding, Biochemistry +10

Halogen Bonding at the Active Sites of Human Cathepsin L and MEK1 Kinase: Efficient Interactions in Different Environments

Leo A. Hardegger, Bernd Kuhn, Beat Spinnler et al. · ChemMedChem · 2011 · 128 citations

New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic α,α-difluoroketone hydrates

C. Fah, Leo A. Hardegger, Lukas Baitsch et al. · Organic & Biomolecular Chemistry · 2009 · 47 citations

Combinatorial Chemistry, Bioorganic Chemistry, Antiparasitic Agent +16

The Discovery of <i>N</i>-(1-Methyl-5-(trifluoromethyl)-1<i>H</i>-pyrazol-3-yl)-5-((6- ((methylamino)methyl)pyrimidin-4-yl)oxy)-1<i>H</i>-indole-1-carboxamide (Acrizanib), a VEGFR-2 Inhibitor Specifically Designed for Topical Ocular Delivery, as a Therapy for Neovascular Age-Related Macular Degeneration

Christopher M. Adams, Karen Anderson, Gerald D. Artman et al. · Journal of Medicinal Chemistry · 2018 · 36 citations · Full text

Ocular Disease, Choroidal Neovascularization, Pharmacotherapy +17

Modular Synthesis of Highly Substituted Pyridines via Enolate α-Alkenylation

Leo A. Hardegger, Jacqueline Habegger, Timothy J. Donohoe · Organic Letters · 2015 · 33 citations

Derivatives, Engineering, Highly Substituted Pyridines +11