Combinatorial Domain Swaps Provide Insights into the Rules of Fungal Polyketide Synthase Programming and the Rational Synthesis of Non‐Native Aromatic Products

Abstract

Playing by the rules: Combinatorial domain swaps among “deconstructed” non-reducing polyketide synthases (NR-PKSs) revealed the rules behind product assembly (see scheme). The control exerted by individual catalytic domains was found to be sufficiently great that heterocombinations of domains from different NR-PKSs synthesized products in a predictable manner. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.