Isao Fujii

Production of ‘hybrid’ antibiotics by genetic engineering

David A. Hopwood, Francisco Malpartida, Helen M. Kieser et al. · Nature · 1985 · 363 citations

Engineering, Biotechnology, Synthetic Biology +5

A new pathway for polyketide synthesis in microorganisms

Nobutaka Funa, Yasuo Ohnishi, Isao Fujii et al. · Nature · 1999 · 295 citations

Biosynthesis, Engineering, Biochemical Engineering +6

Reconstitution of a fungal meroterpenoid biosynthesis reveals the involvement of a novel family of terpene cyclases

Takayuki Itoh, Kinya Tokunaga, Yudai Matsuda et al. · Nature Chemistry · 2010 · 231 citations

Biosynthesis, Terpene Cyclases, Biochemistry +6

Identification of Claisen cyclase domain in fungal polyketide synthase WA, a naphthopyrone synthase of Aspergillus nidulans

Isao Fujii, Akira Watanabe, Ushio Sankawa et al. · Chemistry & Biology · 2001 · 213 citations · Full text

Industrial Mycology, Biosynthesis, Biochemistry +6

Isoliquiritigenin is a potent inhibitor of NLRP3 inflammasome activation and diet-induced adipose tissue inflammation

Hiroe Honda, Yoshinori Nagai, Takayuki Matsunaga et al. · Journal of Leukocyte Biology · 2014 · 207 citations

Discrete Activation Steps, Potent Inhibitor, Inflammasome Activation +20