Concepedia

Polyketide Chain Assembly

Polyketide Chain Assembly is a biosynthetic process in which a polyketide synthase enzyme complex iteratively catalyzes the condensation of acyl-CoA building blocks into a linear polyketide chain through decarboxylative Claisen condensations, distinguished by its programmed selection, modification, and incorporation of extender units to determine chain length, oxidation state, and functional group diversity.

295

Publications

15.5K

Citations

1.1K

Authors

299

Institutions

Publications per year

2017–2026

54

Parents

Publications

295

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.

Joseph P. Noel, Joseph M. Jez, M.E. Bowman et al. · Nature Structural Biology · 1999 · 673 citations

, , +16

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

Jonathan Kennedy, Karine Auclair, Steven G. Kendrew et al. · Science · 1999 · 660 citations

, , +16

Rational design of aromatic polyketide natural products by recombinant assembly of enzymatic subunits

Robert McDaniel, Susanne Ebert‐Khosla, David A. Hopwood et al. · Nature · 1995 · 285 citations

, , +17

The identification of bacillaene, the product of the PksX megacomplex in <i>Bacillus subtilis</i>

Rebecca A. Butcher, Frank C. Schroeder, Michael A. Fischbach et al. · Proceedings of the National Academy of Sciences · 2007 · 281 citations · Full text

, , +16

A chain initiation factor common to both modular and aromatic polyketide synthases

Christian Bisang, Paul F. Long, James Westcott et al. · Nature · 1999 · 279 citations

, , +10

1–5 of 295

Authors

1.1K

  1. CK
    Chaitan Khosla

    Stanford University, United States

    20 publications · 1.3K citations

    19

    h-index

  2. CH
    Christian Hertweck

    Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI), Germany

    16 publications · 903 citations

    15

    h-index

  3. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    15 publications · 1.3K citations

    14

    h-index

  4. DH
    David H. Sherman

    University of Michigan, United States

    14 publications · 877 citations

    14

    h-index

  5. DE
    David E. Cane

    Brown University, United States

    14 publications · 867 citations

    13

    h-index

1–5 of 1.1K

Institutions

299

  1. Stanford University

    Stanford, United States

    19 h-index

    58 publications

    3.8K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    17 h-index

    65 publications

    5.8K citations

  3. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    16 h-index

    71 publications

    3.9K citations

  4. Friedrich Schiller University Jena

    Jena, Germany

    14 h-index

    22 publications

    1.1K citations

  5. Brown University

    Providence, United States

    13 h-index

    29 publications

    1.7K citations

  6. University of Michigan

    Ann Arbor, United States

    11 h-index

    49 publications

    3.4K citations

  7. The University of Tokyo

    Tokyo, Japan

    8 h-index

    20 publications

    419 citations

  8. Chinese Academy of Sciences

    Beijing, China

    7 h-index

    38 publications

    1.7K citations

1–8 of 299

Venues

  1. Chemistry & Biology

    21 publications · 1.3K citations

    20

    h-index

  2. Journal of the American Chemical Society

    JACS · 22 publications · 972 citations

    19

    h-index

  3. Angewandte Chemie International Edition

    21 publications · 1K citations

    18

    h-index

  4. Tetrahedron Letters

    18 publications · 706 citations

    16

    h-index

  5. Biochemistry

    10 publications · 474 citations

    10

    h-index

1–5