James Westcott

A chain initiation factor common to both modular and aromatic polyketide synthases

Christian Bisang, Paul F. Long, James Westcott et al. · Nature · 1999 · 279 citations

Pharmacy, Biochemistry, Molecular Biology +10

The discovery of the potent aurora inhibitor MK-0457 (VX-680)

David Bebbington, Hayley Binch, Jean‐Damien Charrier et al. · Bioorganic & Medicinal Chemistry Letters · 2009 · 99 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +8

First in vitro directed biosynthesis of new compounds by a minimal type II polyketide synthase: evidence for the mechanism of chain length determinationElectronic supplementary information (ESI) available: LCMS spectra and detailed experimental procedures for all reported experiments. See http://www.rsc.org/suppdata/cc/b3/b300847a/

T. P. Nicholson, Christopher J. Winfield, James Westcott et al. · Chemical Communications · 2003 · 52 citations

Life Sciences, Biochemistry, Molecular Biology +9

Streptomyces coelicolor phosphopantetheinyl transferase: a promiscuous activator of polyketide and fatty acid synthase acyl carrier proteins

Russell J. Cox, John Crosby, Oliver Daltrop et al. · Journal of the Chemical Society Perkin Transactions 1 · 2002 · 37 citations

Life Sciences, Biochemistry, Microbiology +17

New 4‐Amino‐1,2,3‐Triazole Inhibitors of Indoleamine 2,3‐Dioxygenase Form a Long‐Lived Complex with the Enzyme and Display Exquisite Cellular Potency

Julie A. C. Alexandre, M.K. Swan, Mike John Latchem et al. · ChemBioChem · 2017 · 37 citations

Pharmacy, Medicinal Chemistry, Pharmacology +11