Concepedia

The discovery of the potent aurora inhibitor MK-0457 (VX-680)

David Bebbington, Hayley Binch, Jean‐Damien Charrier, Simon R. L. Everitt, Damien Fraysse, Julian M.C. Golec, David P. Kay, Ronald M. A. Knegtel, Chau Mak, Francesca Mazzei,

Bioorganic & Medicinal Chemistry Letters · 2009 · 99 citations · 16 references

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Rational design of inhibitors that bind to inactive kinase conformations

Yi Liu, Nathanael S. Gray · Nature Chemical Biology · 2006 · 1.1K citations · Full text

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VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 954 citations · Full text

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Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles

David M. Glover, Mark Harold Leibowitz, Doris McLean et al. · Cell · 1995 · 833 citations · Full text

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Inhibition of drug-resistant mutants of ABL, KIT, and EGF receptor kinases

Todd A. Carter, Lisa Wodicka, Neil P. Shah et al. · Proceedings of the National Academy of Sciences · 2005 · 555 citations · Full text

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MK-0457, a novel kinase inhibitor, is active in patients with chronic myeloid leukemia or acute lymphocytic leukemia with the T315I BCR-ABL mutation

Francis J. Giles, Jörge E. Cortes, Dan Jones et al. · Blood · 2006 · 361 citations · Full text

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