Julian M.C. Golec

VX-680, a potent and selective small-molecule inhibitor of the Aurora kinases, suppresses tumor growth in vivo

Elizabeth A. Harrington, David Bebbington, Jeffrey R. Moore et al. · Nature Medicine · 2004 · 948 citations · Full text

Selective Small-molecule Inhibitor, Signal Transduction, Signaling Pathway +11

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper, Matthew R. Griffiths, Joanna Long et al. · Nature Chemical Biology · 2011 · 631 citations

Tumor Biology, P53-deficient Cancer Cells, Selective Killing +9

Discovery of Potent and Selective Inhibitors of Ataxia Telangiectasia Mutated and Rad3 Related (ATR) Protein Kinase as Potential Anticancer Agents

Jean‐Damien Charrier, Steven J. Durrant, Julian M.C. Golec et al. · Journal of Medicinal Chemistry · 2011 · 256 citations · Full text

Chemoprevention Strategy, Molecular Biology, Molecular Pharmacology +19

The structures of caspases-1, -3, -7 and -8 reveal the basis for substrate and inhibitor selectivity

Yunyi Wei, Ted Fox, Steve P. Chambers et al. · Chemistry & Biology · 2000 · 197 citations · Full text

Protein Function, Signal Transduction, Biochemistry +9

Potentiation of tumor responses to DNA damaging therapy by the selective ATR inhibitor VX-970

Amy B. Hall, Dave Newsome, Yuxin Wang et al. · Oncotarget · 2014 · 189 citations · Full text