Philip M. Reaper

A DNA damage checkpoint response in telomere-initiated senescence

Fabrizio d’Adda di Fagagna, Philip M. Reaper, Lorena Clay-Farrace et al. · Nature · 2003 · 2.7K citations

Chromatin, Genome Instability, Dna Damage +7

Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

Ian Hickson, Yan Zhao, Caroline J. Richardson et al. · Cancer Research · 2004 · 1.2K citations

Specific Inhibitor, Molecular Biology, Cell Cycle +16

Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR

Philip M. Reaper, Matthew R. Griffiths, Joanna Long et al. · Nature Chemical Biology · 2011 · 631 citations

Tumor Biology, P53-deficient Cancer Cells, Selective Killing +9

ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A

Chris T. Williamson, Rowan Miller, Helen N. Pemberton et al. · Nature Communications · 2016 · 375 citations · Full text

Targeting ATR in vivo using the novel inhibitor VE-822 results in selective sensitization of pancreatic tumors to radiation

Emmanouil Fokas, Remko Prevo, John R. Pollard et al. · Cell Death and Disease · 2012 · 353 citations · Full text