Yi Liu

Rational design of inhibitors that bind to inactive kinase conformations

Yi Liu, Nathanael S. Gray · Nature Chemical Biology · 2006 · 1.1K citations · Full text

Medicinal Chemistry, Biochemistry, Protein Folding +11

Targeting Bcr–Abl by combining allosteric with ATP-binding-site inhibitors

Jianming Zhang, Francisco Adrián, Wolfgang Jahnke et al. · Nature · 2010 · 590 citations

Molecular Pharmacology, Drug Target, Medicine +5

Allosteric inhibitors of Bcr-abl–dependent cell proliferation

Francisco Adrián, Qiang Ding, Taebo Sim et al. · Nature Chemical Biology · 2006 · 376 citations · Full text

Molecular Pharmacology, Medicine, Allosteric Inhibitors +5

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Szymon Kłossowski, Hongzhi Miao, Katarzyna Kempińska et al. · Journal of Clinical Investigation · 2019 · 223 citations · Full text

Npm1-mutated Models, Hematological Malignancy, Systems Biology +13

Gut microbiome alterations and gut barrier dysfunction are associated with host immune homeostasis in COVID-19 patients

Zhonghan Sun, Zhigang Song, Chenglin Liu et al. · BMC Medicine · 2022 · 171 citations · Full text