Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Dmitry Borkin, Shihan He, Hongzhi Miao, +20

Cancer Cell

Hematological MalignancyMll LeukemiaPharmacologic InhibitionMedicineMixed-phenotype Acute Leukemia +7

Menin inhibitor MI-3454 induces remission in MLL1-rearranged and NPM1-mutated models of leukemia

Szymon Kłossowski, Hongzhi Miao, Katarzyna Kempińska, +32

Journal of Clinical Investigation

Npm1-mutated ModelsHematological MalignancySystems BiologyMixed LineageMixed-phenotype Acute Leukemia +11

Covalent inhibition of NSD1 histone methyltransferase

Huang Huang, Christina A. Howard, Sergei Zari, +18

Nature Chemical Biology

Histone ModificationsChromatinChromatin RemodelingNatural SciencesEpigenetic Change +7

Synthesis, Structure and Cytotoxic Activity of New Acetylenic Derivatives of Betulin

Stanisław Boryczka, Ewa Bębenek, Joanna Wietrzyk, +4

Molecules

Property Focused Structure-Based Optimization of Small Molecule Inhibitors of the Protein–Protein Interaction between Menin and Mixed Lineage Leukemia (MLL)

Dmitry Borkin, Jonathan Pollock, Katarzyna Kempińska, +10

Journal of Medicinal Chemistry

Small Molecule InhibitorsDrug TargetMolecular BiologyStructure-based OptimizationChemical Biology +17

Synthesis and antiproliferative activity in vitro of new 2-aminobenzimidazole derivatives. Reaction of 2-arylideneaminobenzimidazole with selected nitriles containing active methylene group

Anna M. Nowicka, H. Liszkiewicz, W Nawrocka, +3

Open Chemistry

Bioorganic ChemistryOrganic ChemistryChemistryHeterocycle ChemistryPharmaceutical Chemistry +16

Complexity of Blocking Bivalent Protein–Protein Interactions: Development of a Highly Potent Inhibitor of the Menin–Mixed-Lineage Leukemia Interaction

Dmitry Borkin, Szymon Kłossowski, Jonathan Pollock, +10

Journal of Medicinal Chemistry

Hydroxyethyl starch as an effective methotrexate carrier in anticancer therapy

Tomasz M. Goszczyński, Beata Filip‐Psurska, Katarzyna Kempińska, +2

Pharmacology Research & Perspectives

Tumor BiologyNanomedicineOncologyPolymer-drug ConjugateMedicine +11

Pharmacologic Inhibition of the Menin–MLL Interaction Leads to Transcriptional Repression of <i>PEG10</i> and Blocks Hepatocellular Carcinoma

Katarzyna Kempińska, Bhavna Malik, Dmitry Borkin, +6

Molecular Cancer Therapeutics

Combinatorial treatment with menin and FLT3 inhibitors induces complete remission in AML models with activating FLT3 mutations

Hongzhi Miao, Eungi Kim, Dong Chen, +8

Blood

Combinatorial TreatmentSystems BiologyComplete RemissionAml ModelsRadiation Oncology +5