Concepedia

Shihan He

SH

10

Publications

1.4K

Citations

10

H-Index

2009

Active since

Affiliations

University of Michigan(Current)

University of Virginia

Cornell University

Michigan Medicine

Pennsylvania State University

Shihan He is an author at University of Michigan specializing in medicine, cell biology, and molecular biology.

Top concepts

MedicineCell BiologyMolecular BiologySystems BiologyImmunologyTumor BiologyCell SignalingDrug DiscoveryCancer ResearchSmall Molecules

Publications per year

2009–2021

10

Publications

10

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

Jolanta Grembecka, Shihan He, Aibin Shi et al. · Nature Chemical Biology · 2012 · 429 citations

Hematological Malignancy, Tumor Biology, Mixed-phenotype Acute Leukemia +9

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Dmitry Borkin, Shihan He, Hongzhi Miao et al. · Cancer Cell · 2015 · 394 citations · Full text

Hematological Malignancy, Mll Leukemia, Pharmacologic Inhibition +9

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Aibin Shi, Marcelo J. Murai, Shihan He et al. · Blood · 2012 · 198 citations · Full text

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

Felicia Gray, Hyo Je Cho, Shirish Shukla et al. · Nature Communications · 2016 · 109 citations · Full text

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

Shihan He, Timothy J. Senter, Jonathan Pollock et al. · Journal of Medicinal Chemistry · 2014 · 92 citations · Full text

Menin-mixed Lineage Leukemia, High-affinity Small-molecule Inhibitors, Mixed-phenotype Acute Leukemia +22

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