Shihan He

Menin-MLL inhibitors reverse oncogenic activity of MLL fusion proteins in leukemia

Jolanta Grembecka, Shihan He, Aibin Shi et al. · Nature Chemical Biology · 2012 · 429 citations

Hematological Malignancy, Tumor Biology, Mixed-phenotype Acute Leukemia +9

Pharmacologic Inhibition of the Menin-MLL Interaction Blocks Progression of MLL Leukemia In Vivo

Dmitry Borkin, Shihan He, Hongzhi Miao et al. · Cancer Cell · 2015 · 394 citations · Full text

Hematological Malignancy, Mll Leukemia, Pharmacologic Inhibition +9

Structural insights into inhibition of the bivalent menin-MLL interaction by small molecules in leukemia

Aibin Shi, Marcelo J. Murai, Shihan He et al. · Blood · 2012 · 198 citations · Full text

BMI1 regulates PRC1 architecture and activity through homo- and hetero-oligomerization

Felicia Gray, Hyo Je Cho, Shirish Shukla et al. · Nature Communications · 2016 · 109 citations · Full text

High-Affinity Small-Molecule Inhibitors of the Menin-Mixed Lineage Leukemia (MLL) Interaction Closely Mimic a Natural Protein–Protein Interaction

Shihan He, Timothy J. Senter, Jonathan Pollock et al. · Journal of Medicinal Chemistry · 2014 · 92 citations · Full text

Menin-mixed Lineage Leukemia, High-affinity Small-molecule Inhibitors, Mixed-phenotype Acute Leukemia +22