Concepedia

Polyketide Biosynthesis

Polyketide Biosynthesis is a metabolic pathway category within natural product biosynthesis that involves the enzymatic assembly of polyketide scaffolds through the sequential condensation of acyl-CoA precursors, distinguished by the action of polyketide synthase enzymes and structural diversification mechanisms.

4.1K

Publications

233.8K

Citations

12.6K

Authors

2.1K

Institutions

Publications per year

2017–2026

952

Parents

Children

Publications

4.1K

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system

Daniel Tillett, Elke Dittmann, Marcel Erhard et al. · Chemistry & Biology · 2000 · 997 citations · Full text

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Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science · 1991 · 909 citations

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Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes

James G. Metz, Paul G. Roessler, Daniel Facciotti et al. · Science · 2001 · 771 citations

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Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of <i>E. coli</i>

Blaine A. Pfeifer, Suzanne J. Admiraal, Hugo Gramajo et al. · Science · 2001 · 760 citations

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Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.

Joseph P. Noel, Joseph M. Jez, M.E. Bowman et al. · Nature Structural Biology · 1999 · 673 citations

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1–5 of 4.1K

Authors

12.6K

  1. CK
    Chaitan Khosla

    Stanford University, United States

    156 publications · 12.3K citations

    66

    h-index

  2. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    123 publications · 8.5K citations

    54

    h-index

  3. DE
    David E. Cane

    Brown University, United States

    94 publications · 7.2K citations

    51

    h-index

  4. DH
    David H. Sherman

    University of Michigan, United States

    88 publications · 6.6K citations

    47

    h-index

  5. YT
    Yi Tang

    University of California, Los Angeles, United States

    72 publications · 5.1K citations

    45

    h-index

1–5 of 12.6K

Institutions

2.1K

  1. Stanford University

    Stanford, United States

    64 h-index

    528 publications

    38.3K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    57 h-index

    706 publications

    56.3K citations

  3. University of Wisconsin–Madison

    Madison, United States

    56 h-index

    380 publications

    29.7K citations

  4. The University of Tokyo

    Tokyo, Japan

    53 h-index

    480 publications

    31.6K citations

  5. Brown University

    Providence, United States

    49 h-index

    276 publications

    19.9K citations

  6. Chinese Academy of Sciences

    Beijing, China

    49 h-index

    833 publications

    38.5K citations

  7. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    48 h-index

    434 publications

    22.3K citations

  8. University of California, Los Angeles

    Los Angeles, United States

    45 h-index

    266 publications

    21K citations

1–8 of 2.1K

Venues

  1. Journal of the American Chemical Society

    JACS · 306 publications · 20.2K citations

    80

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 101 publications · 15.4K citations

    69

    h-index

  3. Chemistry & Biology

    110 publications · 10.9K citations

    64

    h-index

  4. Journal of Biological Chemistry

    JBC · 110 publications · 8.2K citations

    58

    h-index

  5. Journal of Bacteriology

    JB · 96 publications · 9.6K citations

    58

    h-index

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