Concepedia

Enediyne Biosynthesis

Enediyne Biosynthesis is a specialized biosynthetic pathway within polyketide metabolism that generates enediyne natural products through a distinct enzymatic cascade characterized by the formation of a hallmark 9-membered enediyne core via iterative polyketide synthase machinery and unique post-polyketidation modifications.

107

Publications

5.5K

Citations

373

Authors

112

Institutions

Publications per year

2017–2026

17

Parents

Publications

107

The chemistry of enediynes, enyne allenes and related compounds

Janet Wisniewski Grissom, G. U. GUNAWARDENA, Detlef Klingberg et al. · Tetrahedron · 1996 · 405 citations

, , +6

The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS

Joachim Ahlert, Erica M. Shepard, Natalia Lomovskaya et al. · Science · 2002 · 291 citations

, , +10

Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

Wen Liu, Steven D. Christenson, Scott Standage et al. · Science · 2002 · 282 citations

, , +17

Cyanosporasides A and B, Chloro- and Cyano-cyclopenta[ <i>a</i> ]indene Glycosides from the Marine Actinomycete “ <i>Salinispora pacifica</i> ”

Dong‐Chan Oh, Philip G. Williams, Christopher A. Kauffman et al. · Organic Letters · 2006 · 160 citations

, , +14

Design, synthesis, and study of simple monocyclic conjugated enediynes. The 10-membered ring enediyne moiety of the enediyne anticancer antibiotics

K. C. Nicolaou, Guido Zuccarello, Claus Riemer et al. · Journal of the American Chemical Society · 1992 · 157 citations

, , +14

1–5 of 107

Authors

373

  1. BS
    Ben Shen

    University of Wisconsin–Madison, United States

    28 publications · 1.5K citations

    20

    h-index

  2. DY
    Dong Yang

    Scripps Research Institute, United States

    8 publications · 292 citations

    8

    h-index

  3. SG
    Steven G. Van Lanen

    University of Kentucky, United States

    7 publications · 399 citations

    7

    h-index

  4. XY
    Xiaohui Yan

    Scripps Research Institute, United States

    7 publications · 329 citations

    7

    h-index

  5. JS
    Jon S. Thorson

    University of Kentucky, United States

    7 publications · 658 citations

    7

    h-index

1–5 of 373

Institutions

112

  1. University of Wisconsin–Madison

    Madison, United States

    15 h-index

    62 publications

    5.5K citations

  2. Scripps Research Institute

    San Diego, United States

    12 h-index

    91 publications

    3.8K citations

  3. University of California San Diego

    San Diego, United States

    9 h-index

    38 publications

    3.2K citations

  4. Scripps Institution of Oceanography

    La Jolla, United States

    7 h-index

    34 publications

    3.2K citations

  5. Nanyang Technological University

    Singapore, Singapore

    6 h-index

    50 publications

    2.1K citations

  6. Johns Hopkins University

    Baltimore, United States

    6 h-index

    12 publications

    552 citations

  7. Pharmaceutical Biotechnology (Czechia)

    Prague, Czechia

    5 h-index

    13 publications

    1.3K citations

  8. Tokushima University

    Tokushima, Japan

    5 h-index

    21 publications

    494 citations

1–8 of 112

Venues

  1. Journal of the American Chemical Society

    JACS · 14 publications · 939 citations

    14

    h-index

  2. Tetrahedron Letters

    16 publications · 480 citations

    14

    h-index

  3. Organic Letters

    OL · 8 publications · 368 citations

    8

    h-index

  4. Tetrahedron

    6 publications · 581 citations

    6

    h-index

  5. Angewandte Chemie International Edition

    5 publications · 184 citations

    5

    h-index

1–5