Concepedia

Iterative Polyketide Biosynthesis

Iterative Polyketide Biosynthesis is a biosynthetic mechanism in which a single multidomain polyketide synthase enzyme repetitively employs its catalytic domains to perform multiple rounds of chain elongation and modification, distinguished from modular systems by the reuse of catalytic components for successive extension cycles.

117

Publications

9K

Citations

507

Authors

135

Institutions

Publications per year

2017–2026

19

Parents

Publications

117

Modulation of Polyketide Synthase Activity by Accessory Proteins During Lovastatin Biosynthesis

Jonathan Kennedy, Karine Auclair, Steven G. Kendrew et al. · Science · 1999 · 660 citations

, , +16

Complete Reconstitution of a Highly Reducing Iterative Polyketide Synthase

Magali Suzanne, Jesse W.-H. Li, Jin Wook Choi et al. · Science · 2009 · 385 citations · Full text

, , +17

Evolutionary Implications of Bacterial Polyketide Synthases

Holger Jenke‐Kodama, Axel Sandmann, Rolf Müller et al. · Molecular Biology and Evolution · 2005 · 369 citations · Full text

, , +17

The Calicheamicin Gene Cluster and Its Iterative Type I Enediyne PKS

Joachim Ahlert, Erica M. Shepard, Natalia Lomovskaya et al. · Science · 2002 · 291 citations

, , +10

Biosynthesis of the Enediyne Antitumor Antibiotic C-1027

Wen Liu, Steven D. Christenson, Scott Standage et al. · Science · 2002 · 282 citations

, , +17

1–5 of 117

Authors

507

  1. YT
    Yi Tang

    University of California, Los Angeles, United States

    17 publications · 1.6K citations

    17

    h-index

  2. CA
    Craig A. Townsend

    Johns Hopkins University, United States

    10 publications · 839 citations

    10

    h-index

  3. JC
    John C. Vederas

    University of Alberta, Canada

    9 publications · 1.6K citations

    9

    h-index

  4. CH
    Christian Hertweck

    Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI), Germany

    9 publications · 572 citations

    9

    h-index

  5. WX
    Wei Xu

    University of California, Los Angeles, United States

    8 publications · 407 citations

    8

    h-index

1–5 of 507

Institutions

135

  1. University of California, Los Angeles

    Los Angeles, United States

    17 h-index

    75 publications

    7.2K citations

  2. University of Wisconsin–Madison

    Madison, United States

    11 h-index

    37 publications

    5.9K citations

  3. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    11 h-index

    43 publications

    1.9K citations

  4. Johns Hopkins University

    Baltimore, United States

    10 h-index

    45 publications

    4.1K citations

  5. University of Alberta

    Edmonton, Canada

    9 h-index

    35 publications

    4.5K citations

  6. The University of Tokyo

    Tokyo, Japan

    8 h-index

    28 publications

    2.2K citations

  7. University of Cambridge

    Cambridge, United Kingdom

    7 h-index

    22 publications

    1.5K citations

  8. Friedrich Schiller University Jena

    Jena, Germany

    6 h-index

    10 publications

    346 citations

1–8 of 135

Venues

  1. Journal of the American Chemical Society

    JACS · 20 publications · 1.3K citations

    20

    h-index

  2. Angewandte Chemie International Edition

    10 publications · 398 citations

    10

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 9 publications · 982 citations

    9

    h-index

  4. Chemistry & Biology

    9 publications · 891 citations

    9

    h-index

  5. ChemBioChem

    9 publications · 432 citations

    9

    h-index

1–5