Concepedia

Polyketide Synthase Pathways

Polyketide Synthase Pathways is a biosynthetic mechanism in marine natural product metabolism that directs the stepwise assembly of polyketide secondary metabolites through the sequential condensation of acyl-CoA precursors mediated by modular enzymatic domains.

1.7K

Publications

110.8K

Citations

5.7K

Authors

1.2K

Institutions

Publications per year

2017–2026

376

Variants

Pks Pathways

Parents

Publications

1.7K

Structural organization of microcystin biosynthesis in Microcystis aeruginosa PCC7806: an integrated peptide–polyketide synthetase system

Daniel Tillett, Elke Dittmann, Marcel Erhard et al. · Chemistry & Biology · 2000 · 997 citations · Full text

, , +11

Modular Organization of Genes Required for Complex Polyketide Biosynthesis

Stefano Donadio, Michael J. Staver, James B. McAlpine et al. · Science · 1991 · 909 citations

, , +17

Production of Polyunsaturated Fatty Acids by Polyketide Synthases in Both Prokaryotes and Eukaryotes

James G. Metz, Paul G. Roessler, Daniel Facciotti et al. · Science · 2001 · 771 citations

, , +17

Biosynthesis of Complex Polyketides in a Metabolically Engineered Strain of <i>E. coli</i>

Blaine A. Pfeifer, Suzanne J. Admiraal, Hugo Gramajo et al. · Science · 2001 · 760 citations

, , +17

Structure of chalcone synthase and the molecular basis of plant polyketide biosynthesis.

Joseph P. Noel, Joseph M. Jez, M.E. Bowman et al. · Nature Structural Biology · 1999 · 673 citations

, , +16

1–5 of 1.7K

Authors

5.7K

  1. CK
    Chaitan Khosla

    Stanford University, United States

    87 publications · 7.2K citations

    48

    h-index

  2. PF
    Peter F. Leadlay

    University of Cambridge, United Kingdom

    79 publications · 6K citations

    44

    h-index

  3. DH
    David H. Sherman

    University of Michigan, United States

    54 publications · 4.3K citations

    38

    h-index

  4. JS
    James Staunton

    University of Cambridge, United Kingdom

    47 publications · 3.7K citations

    33

    h-index

  5. CR
    C. Richard Hutchinson

    University of Wisconsin–Madison, United States

    37 publications · 3.4K citations

    32

    h-index

1–5 of 5.7K

Institutions

1.2K

  1. University of Cambridge

    Cambridge, United Kingdom

    46 h-index

    412 publications

    37.6K citations

  2. Stanford University

    Stanford, United States

    45 h-index

    289 publications

    21.1K citations

  3. University of Wisconsin–Madison

    Madison, United States

    44 h-index

    221 publications

    18.1K citations

  4. The University of Tokyo

    Tokyo, Japan

    43 h-index

    277 publications

    18K citations

  5. Brown University

    Providence, United States

    32 h-index

    149 publications

    9.4K citations

  6. Leibniz-Institut für Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Knöll-Institut (HKI)

    Jena, Germany

    32 h-index

    201 publications

    11.7K citations

  7. Chinese Academy of Sciences

    Beijing, China

    31 h-index

    225 publications

    12.4K citations

  8. University of Michigan

    Ann Arbor, United States

    31 h-index

    206 publications

    17.4K citations

1–8 of 1.2K

Venues

  1. Journal of the American Chemical Society

    JACS · 141 publications · 9.7K citations

    62

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 60 publications · 9.9K citations

    50

    h-index

  3. Chemistry & Biology

    71 publications · 7.4K citations

    49

    h-index

  4. ChemBioChem

    81 publications · 3.8K citations

    38

    h-index

  5. Journal of Biological Chemistry

    JBC · 47 publications · 4.1K citations

    37

    h-index

1–5