Concepedia

Nicastrin Is Required for γ-Secretase Cleavage of the Drosophila Notch Receptor

Yue Hu, Yihong Ye, Mark Fortini

Developmental Cell · 2002 · 173 citations · 43 references

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References

43

Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and γ-secretase activity

Michael S. Wolfe, Weiming Xia, Beth L. Ostaszewski et al. · Nature · 1999 · 1.9K citations

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Deficiency of presenilin-1 inhibits the normal cleavage of amyloid precursor protein

Bart De Strooper, Paul Säftig, Katleen Craessaerts et al. · Nature · 1998 · 1.8K citations

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A Novel Proteolytic Cleavage Involved in Notch Signaling

Christel Brou, Frédérique Logeat, Neetu Gupta et al. · Molecular Cell · 2000 · 1.1K citations · Full text

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Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats

Kristi A. Wharton, Kristen M. Johansen, Tian Xu et al. · Cell · 1985 · 1.1K citations

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Endoproteolysis of Presenilin 1 and Accumulation of Processed Derivatives In Vivo

Gopal Thinakaran, David Borchelt, Michael K. Lee et al. · Neuron · 1996 · 1K citations · Full text

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