Nature Chemical Biology · 2015 · 434 citations · 27 references
Life SciencesBiotechnologyMolecular BiologyGene TherapyGenome EditingGenome EngineeringCrispr-cas SystemsGuide Rna DesignOff-target EffectsTarget Site SelectionTherapeutic Genome EditingCas Protein EngineeringCas9 Off-target ActivityCrispr-cas Genome EditingCrispr-cas9 Genome EditingCrispr-cas9 Mediated Knock-inGenome Editing Specificity
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A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity
Martin Jínek, Krzysztof Chylinski, Ines Fonfara et al. · Science · 2012 · 17.3K citations · Full text
Multiplex Genome Engineering Using CRISPR/Cas Systems
Le Cong, F. Ann Ran, David Cox et al. · Science · 2013 · 15.7K citations
RNA-Guided Human Genome Engineering via Cas9
Prashant Mali, Luhan Yang, Kevin M. Esvelt et al. · Science · 2013 · 9.4K citations · Full text
DNA targeting specificity of RNA-guided Cas9 nucleases
Patrick D. Hsu, David A. Scott, Joshua A. Weinstein et al. · Nature Biotechnology · 2013 · 4.9K citations · Full text
Double Nicking by RNA-Guided CRISPR Cas9 for Enhanced Genome Editing Specificity
F. Ann Ran, Patrick D. Hsu, Chie-Yu Lin et al. · Cell · 2013 · 3.4K citations · Full text