Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

John A. Zuris, David B. Thompson, Yilai Shu, +7

Nature Biotechnology

Lipid PreparationIn Vivo Gene TherapyBiochemistryNatural SciencesMolecular Biology +8

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

John P. Guilinger, David B. Thompson, David R. Liu

Nature Biotechnology

EngineeringGenome ModificationMedicineMolecular BiologyGenetic Engineering +7

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Xue Gao, Yong Tao, Verónica Lamas, +16

Nature

Genome Editing AgentsDevelopmental BiologyIn Vivo Gene TherapyGeneticsAudiology +11

Small molecule–triggered Cas9 protein with improved genome-editing specificity

Kevin M Davis, Vikram Pattanayak, David B. Thompson, +2

Nature Chemical Biology

Natural SciencesCas9 ProteinMolecular BiologyGenome EngineeringGenome Editing +3

Mammalian cell penetration, siRNA transfection, and DNA transfection by supercharged proteins

Brian R. McNaughton, James J. Cronican, David B. Thompson, +1

Proceedings of the National Academy of Sciences

Multisystem inflammatory syndrome in children is driven by zonulin-dependent loss of gut mucosal barrier

Lael M. Yonker, Tal Gilboa, Alana F. Ogata, +30

Journal of Clinical Investigation

Rapid Assembly of Complex 3D Siloxane Architectures

David B. Thompson, Michael A. Brook

Journal of the American Chemical Society

Supramolecular AssemblyEngineeringOrganic ChemistryChemistryChemical Engineering +18

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

Margie Li, Yong Tao, Yilai Shu, +6

Journal of the American Chemical Society

Protein SecretionPeptide EngineeringEndosomal EscapeMolecular BiologyPeptide Science +18

Engineering and Identifying Supercharged Proteins for Macromolecule Delivery into Mammalian Cells

David B. Thompson, James J. Cronican, David R. Liu

Methods in enzymology on CD-ROM/Methods in enzymology

Cell-based Drug DeliveryMammalian CellsMedicineMacromolecule DeliveryBioconjugation +7

Cellular Uptake Mechanisms and Endosomal Trafficking of Supercharged Proteins

David B. Thompson, Roberto Villaseñor, Brent M. Dorr, +2

Chemistry & Biology

Protein FoldingEndocytic PathwayMolecular BiologyProtein TransportIntracellular Trafficking +3