John P. Guilinger

High-throughput profiling of off-target DNA cleavage reveals RNA-programmed Cas9 nuclease specificity

Vikram Pattanayak, Steven Lin, John P. Guilinger et al. · Nature Biotechnology · 2013 · 1.5K citations · Full text

Off-target Effect, Functional Genomics, Medicine +10

Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

John A. Zuris, David B. Thompson, Yilai Shu et al. · Nature Biotechnology · 2014 · 1.4K citations · Full text

Lipid Preparation, In Vivo Gene Therapy, Biochemistry +10

Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

John P. Guilinger, David B. Thompson, David R. Liu · Nature Biotechnology · 2014 · 837 citations · Full text

Engineering, Genome Modification, Medicine +9

Broad specificity profiling of TALENs results in engineered nucleases with improved DNA-cleavage specificity

John P. Guilinger, Vikram Pattanayak, Deepak Reyon et al. · Nature Methods · 2014 · 213 citations · Full text

Machine Learning on DNA-Encoded Libraries: A New Paradigm for Hit Finding

Kevin McCloskey, Eric A. Sigel, Steven Kearnes et al. · Journal of Medicinal Chemistry · 2020 · 157 citations · Full text