Cationic lipid-mediated delivery of proteins enables efficient protein-based genome editing in vitro and in vivo

John A. Zuris, David B. Thompson, Yilai Shu, +7

Nature Biotechnology

Lipid PreparationIn Vivo Gene TherapyBiochemistryNatural SciencesMolecular Biology +8

Treatment of autosomal dominant hearing loss by in vivo delivery of genome editing agents

Xue Gao, Yong Tao, Verónica Lamas, +16

Nature

Genome Editing AgentsDevelopmental BiologyIn Vivo Gene TherapyGeneticsAudiology +11

AAV1-hOTOF gene therapy for autosomal recessive deafness 9: a single-arm trial

Jun Lv, Hui Wang, Xiaoting Cheng, +24

The Lancet

Gene TherapiesAav1-hotof Gene TherapySingle-arm TrialGeneticsAudiology +4

Autophagy protects auditory hair cells against neomycin-induced damage

Zuhong He, Lingna Guo, Yilai Shu, +14

Autophagy

Cell AutophagyMitophagySelective AutophagyOxidative StressMedicine +13

Olfactory and Gustatory Dysfunction as an Early Identifier of COVID‐19 in Adults and Children: An International Multicenter Study

Chenghao Qiu, Chong Cui, Charlotte Hautefort, +26

Otolaryngology

AAV‐Mediated Gene Therapy Restores Hearing in Patients with DFNB9 Deafness

Jieyu Qi, Fangzhi Tan, Liyan Zhang, +22

Advanced Science

Chimeric Antigen Receptor Designed to Prevent Ubiquitination and Downregulation Showed Durable Antitumor Efficacy

Wentao Li, Shizhen Qiu, Jian Chen, +12

Immunity

Chimeric Antigen ReceptorImmunologyAntigen ProcessingAntibody EngineeringImmunotherapy +2

Discovery and Characterization of a Peptide That Enhances Endosomal Escape of Delivered Proteins in Vitro and in Vivo

Margie Li, Yong Tao, Yilai Shu, +6

Journal of the American Chemical Society

Protein SecretionPeptide EngineeringEndosomal EscapeMolecular BiologyPeptide Science +18

Renewed proliferation in adult mouse cochlea and regeneration of hair cells

Yilai Shu, Wenyan Li, Mingqian Huang, +10

Nature Communications

Identification of Adeno-Associated Viral Vectors That Target Neonatal and Adult Mammalian Inner Ear Cell Subtypes

Yilai Shu, Tao Yong, Zhengmin Wang, +5

Human Gene Therapy

Adeno-associated Viral VectorsReporter Gene GfpDevelopmental BiologyMolecular VirologyTarget Neonatal +13