Limited influence of <i>UGT1A1*28</i> and no effect of <i>UGT2B7*2</i> polymorphisms on UGT1A1 or UGT2B7 activities and protein expression in human liver microsomes

Abstract

Relative to the observed 16-fold variability in UGT1A1 activity, these data indicate only a partial (approximately 40%) contribution of the UGT1A1*28 polymorphism to variability of interindividual differences in UGT1A1 enzyme activity. For the UGT2B7*2 polymorphism, genotype had no influence on immunoreactive UGT2B7 protein or the rate of 3'-azido-3'-deoxythymidine glucuronidation.