Biocatalytic Synthesis of Quercetin 3‐<i>O</i>‐Glucoside‐7‐<i>O</i>‐Rhamnoside by Metabolic Engineering of <i>Escherichia coli</i>

Abstract

You are what you eat: Quercetin 3-O-glucoside-7-O-rhamnoside is a rare natural product with potential biological importance. We describe a strategy for the regioselective synthesis of this bisglycoside by feeding quercetin 3-O-glucoside, a naturally abundant precursor, to metabolically engineered Escherichia coli. As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.